FIGURE 7.

Relationship between respiratory microbiota and tumor infiltrating lymphocytes in patients with non‐small‐cell lung cancer. A, Boxplot of CD8⁺ T cell density in treatment responders (R) and nonresponders (NR). **0.001 ≤ P < .01 by Mann‐Whitney test. B, Pairwise Spearman’s rank correlation heatmap between featured respiratory microbes and CD4⁺ T cells, CD8⁺ T cells, IFN‐γ⁺CD4⁺ T cells (Th1), IL‐4⁺CD4⁺ T cells (Th2), FoxP3⁺CD4⁺ T cells (Treg). **0.001 ≤ P < .01. C, Univariate linear regression between CD8⁺ T cell density and the abundance of Streptococcus. D, Representative CD8⁺ immunohistochemistry images showing high and low abundance of Streptococcus groups