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. 2021 Jul 5;112(8):3125–3135. doi: 10.1111/cas.14998

FIGURE 4.

FIGURE 4

Validation of the ability of the gut microbiome profile to predict high‐risk prostate cancer (PCa). A, Receiver operating characteristic (ROC) curve analysis of Rikenellaceae (blue line), Alistipes (green line), and Lachnospira (red line) for predicting high‐risk PCa in the test cohort. B, Consort flow diagram of the fecal microbiome prostate index (FMPI) definition. From the 724 operational taxonomic units (OTUs) in the discovery cohort, least absolute shrinkage and selection operator regression analysis selected 18 OTUs that had a strong correlation with either the presence or absence of high‐risk PCa and developed a regression equation for high‐risk PCa detection, which was named FMPI. C, Dot plots depicting FMPI values in the negative + low‐risk and the high‐risk groups in the discovery (left) and test (right) cohorts. D and E, ROC curve analysis and area under the curve of FMPI (blue line) and prostate‐specific antigen level (red line), and cut‐off points of the FMPI for predicting high‐risk PCa in the discovery (D) and test (E) cohorts