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The antiproliferative effect is related closely to the inhibition of proteasome ubiquitin processing by VLX1570. The cells were treated with or without 50 or 100 nmol/L of VLX1570 for 6 h and cell lysates were analyzed by immunoblotting analysis for detection of high molecular weight polyubiquitinated proteins (A) and HSP70 (B). The amount of β‐actin is shown as a loading control
