FIGURE 7.

Schematic diagram of azithromycin (AZM)‐enhanced lysosomal membrane permeabilization (LMP) and cell death induction of DNA‐damaging drugs. DNA‐damaging drugs induce lysosomal membrane damage and lysosomal biogenesis via p53/TFEB activation. AZM blocks autophagy, as well as lysophagy, leading to the accumulation of lysosomes/autolysosomes. Combination treatment with DNA‐damaging drugs and AZM results in the accumulation of damaged lysosomes having LMP, leading to the leakage of lysosomal enzymes, followed by pronounced induction of apoptosis. Red circles: lysosomes/autolysosomes. Dashed red line circle: lysosomes/autolysosomes with LMP. Blue dots: lysosomal enzymes