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. 2021 Jun 12;112(8):3190–3204. doi: 10.1111/cas.14987

FIGURE 1.

FIGURE 1

Expression of fucosyltransferase 8 (FUT8) in breast cancer (BC) clinical samples. A, Core α1,6–fucosylated N‐glycans catalyzed by FUT8 and terminal α‐1,2,3,4–fucosylated N‐glycans catalyzed by FUT1‐7,9 recognized, respectively, by Lens culinaris agglutinin (LcH) and Aleuria aurantia lectin (AAL) lectins. B, Fold changes of FUT1‐11 expression in 18 types of tumor tissues (T) versus corresponding normal tissues (N), based on mRNA microarray data extracted from The Cancer Genome Atlas (TCGA). Red: log2(T_median/N_median) > 0. Green: log2(T_median/N_median) < 0. C, Average expression of 11 different fucosyltransferases in 1659 total BC samples from six BC Gene Expression Omnibus (GEO) datasets (GSE29431, GSE102484, GSE36771, GSE5460, GSE21653, GSE12276, GSE29271). D, Representative FUT8 expression and hematoxylin and eosin (H&E) staining in BC nest‐like structures and adjacent noncancerous cells. E, FUT8 expression in 11 pairs of human breast ductal carcinoma tissues (T) and matched adjacent normal breast tissues (N)