FIGURE 7.

AP‐2γ overexpression or fucosyltransferase 8 (FUT8) knockdown suppresses tumor growth and metastasis in vivo. A, In vivo xenograft experiment (schematic). BALB/c‐nu mice were injected with AP‐2γ–overexpressing (AP‐2γ OE), FUT8‐knockdown (FUT8 sh#1), or vector blank (vector) MDA‐MB‐231. B, Subcutaneous (s.c.) tumor growth curves (n = 6). C, Isolated s.c. tumors of xenograft models and weights of tumors from various groups. D, E, Photographs of splenic tumors and liver metastatic tumors. Right: representative tumor weights for various groups (n = 4 for each group). F, G, Representative H&E and IHC staining images of s.c. tumors