. 2021 Aug 10;22:527. doi: 10.1186/s13063-021-05504-1

Table 1.

Participant inclusion, exclusion and withdrawal criteria

Inclusion criteria	Exclusion criteria	Withdrawal criteria
· Patients of both sexes attending the clinic with periodontal disease · Over the age 19 (no upper age restriction) · Be able to provide informed, written, or verbal consent	· Demonstrating HbA1c levels greater than 8% in the previous 3 months · Chronic GI conditions (e.g., colon cancer, inflammatory bowel disease, celiac disease) and infections · Current or previous use of antibiotics for management of non-periodontal conditions within the past 4 weeks · Individuals who cannot stop taking laxatives, prebiotics, probiotics and/or fiber supplements 2 weeks prior to the start of the intervention and for the duration of the study · Smokers and/or cannabis users · Pregnant or lactating	· Patients with severe periodontal disease that require antibiotics with ST as part of their treatment · Patients who do not show for Visit II or Visit III

Inclusion criteria

Exclusion criteria

Withdrawal criteria

· Patients of both sexes attending the clinic with periodontal disease

· Over the age 19 (no upper age restriction)

· Be able to provide informed, written, or verbal consent

· Demonstrating HbA1c levels greater than 8% in the previous 3 months

· Chronic GI conditions (e.g., colon cancer, inflammatory bowel disease, celiac disease) and infections

· Current or previous use of antibiotics for management of non-periodontal conditions within the past 4 weeks

· Individuals who cannot stop taking laxatives, prebiotics, probiotics and/or fiber supplements 2 weeks prior to the start of the intervention and for the duration of the study

· Smokers and/or cannabis users

· Pregnant or lactating

· Patients with severe periodontal disease that require antibiotics with ST as part of their treatment

· Patients who do not show for Visit II or Visit III