. 2021 Jun 17;112(8):3375–3387. doi: 10.1111/cas.14977

TABLE 1.

Patients and tumour characteristics

Case	Age/gender	Tumor size (cm)	Fuhrman grade	TNM stage^a	Histology^b	Outcome^c	SDHA		VHL	Others	RCC Family histoly	Uterine leiomyomatosis
Case	Age/gender	Tumor size (cm)	Fuhrman grade	TNM stage^a	Histology^b	Outcome^c	Tumor/blood	Immunohistochemistry	Tumor	Tumor	RCC Family histoly	Uterine leiomyomatosis
1	48/F	9	3	pT3aN1M1 (PUL, OSS)	Eosinophilic variant of ccRCC	DOD, 7 mo	c.163T>C p.Tyr55His	Lower	None	RET: c.3275A>G, p.Asn1092Ser	None	None
2	63/M	11	4	pT3bN0M1 (PUL)	pRCC2	DOD, 13 mo	c.1969G>A p.Val657Ile	Moderate	None	PBRM1: c.3215_3216insT, p.Ala1073fs	None
3	67/M	11	3	pT3aN0M1 (PUL)	ccRCC	AWD, 95 mo	c.163T>C p.Tyr55His	Moderate	c.449delA, p.Asn150fs		None
4‐1	66/M	6	3	pT1bN0M0	ccRCC	NED, 97 mo	c.1969G>A p.Val657Ile	Lower	c.292T>A, p.Tyr98Asn		RCC in son (case 4‐2) and paternal cousin
4‐2	46/M	9	3	pT3aN0M1 (PUL)	ccRCC	AWD, 38 mo	c.1969G>A p.Val657Ile	Lower	c.563T>C, p.Leu188Pro		RCC in father (case 4‐1)
5‐1	34/F	8	2	pT3aN0M0	pRCC2	NED, 90 mo	c.550G>A p.Gly184Arg	Moderate	None	RET: c.2166G>A, p.Val706Met	RCC in father (case 5‐2)	None
5‐2	66/M	13	3	pT3aN2M1 (PUL, OSS)	pRCC2	AWD, 19 mo	c.550G>A p.Gly184Arg	Moderate	None	Akt1: c.726delG, p.Glu242fs RET: c.2166G>A, p.Val706Met	RCC in daughter (case 5‐1)
6	32/M	3	2	pT1aN0M0	pRCC2	NED, 27 mo	c.1969G>A p.Val657Ile	Lower	None		None
7	69/M	9	3	pT2aN0M0	pRCC2	NED, 27 mo	c.1969G>A p.Val657Ile	Moderate	None	PBRM1: c.4337_4338insG, p.Gly1447fs	RCC in father
8	49/F	12	3	pT3aN0M1 (PUL, OSS)	Eosinophilic variant of ccRCC	AWD, 7 mo	c.550G>A p.Gly184Arg	Moderate	None	PBRM1: c.2567G>C, p.Arg856Pro; c.4337_4338insG, pGly1447fs RET: c.1465G>A, p.Asp489Asn	None	None
9	71/F	2	3	pT1aN0M0	pRCC2	NED, 7 mo	c.163T>C p.Tyr55His	Lower	None		None	Hysterectomy

^{^a}

Metastatic (M) lesions: PUL, lung; OSS, bone.

^{^b}

Histology: ccRCC, clear cell renal cell carcinoma; pRCC2, papillary type 2 renal cell carcinoma.

^{^c}

Outcome: DOD, dead of disease; AWD, alive with disease; NED, no evidence of disease.