TABLE 2.
Relationship between succinate dehydrogenase (SDH) A gene mutation and proteins (n = 30)
| Immunohistochemistry | |||||
|---|---|---|---|---|---|
| SDHA protein | |||||
| Strong (diffused positive) (n = 17) | Moderate (n = 7) | Lower (n = 6) | P value | ||
| SDHA gene | Mutation (−) (n = 19) | 17 | 1 | 1 | <.0001 |
| Mutation (+) (n = 11) | 0 | 6 | 5 | ||
| SDHB protein | |||||
| Strong (diffused positive) (n = 17) | Moderate (n = 5) | Lower (n = 8) | P value | ||
| SDHA gene | Mutation (−) (n = 19) | 17 | 1 | 1 | <.0001 |
| Mutation (+) (n = 11) | 0 | 4 | 7 | ||
| SDHB protein | |||||
| Strong (diffused positive) (n = 17) | Moderate (n = 5) | Lower (n = 8) | P value | ||
| SDHA protein | Strong (diffused positive) (n = 17) | 17 | 0 | 0 | <.0001 |
| Moderate (n = 7) | 0 | 5 | 2 | ||
| Lower (n = 6) | 0 | 0 | 6 | ||
| Nrf2 protein | |||||
| High (n = 17) | Low (n = 13) | P value | |||
| SDHA gene | Mutation (−) (n = 19) | 7 | 12 | .0067 | |
| Mutation (+) (n = 11) | 10 | 1 | |||
| SDHA protein | |||||
| Strong (diffused positive) (n = 17) | Moderate (n = 7) | Lower (n = 6) | P value | ||
| Nrf2 protein | High (n = 17) | 5 | 6 | 6 | .0023 |
| Low (n = 13) | 12 | 1 | 0 | ||
| SDHB protein | |||||
| Strong (diffused positive) (n = 17) | Moderate (n = 5) | Lower (n = 8) | P value | ||
| Nrf2 protein | High (n = 17) | 5 | 5 | 7 | .0024 |
| Low (n = 13) | 12 | 0 | 1 |