FIGURE 4.

Knockdown of cyclin‐dependent kinase‐like 3 (CDKL3) inhibits tumor growth in vivo. A, Volume of tumors in the normal control (shCtrl) group and shCDKL3 group was measured at 7, 10, 13, 16, 19, 22, 25, 28 days postinjection. B, Average weight of tumors removed from shCtrl and shCDKL3 groups. C, Tumor images taken from mice in shCtrl and shCDKL3 groups. D, Immunohistochemistry was used to detect the expression of Ki‐67 and CDKL3 in tumor tissues removed from mice in shCtrl and shCDKL3 groups. E, Intracranial growth of tumor on brain tissue of mice in shCtrl and shCDKL3 groups. F, Before they were killed, mice were subjected to in vivo imaging to evaluate the growth of intracranial growth of glioma. Data are presented as mean ± SD. *P < .05, ***P < .001