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. Author manuscript; available in PMC: 2021 Aug 10.
Published in final edited form as: FASEB J. 2020 Jul 30;34(9):12239–12254. doi: 10.1096/fj.202000017RR

Figure. 1.

Figure. 1

Pitx3-A53T α-Syn × Tau−/− mice showed anxious behavior at 12-month-old. (A) All the mice were weighed monthly for 18 months (M). (B) The latency to fall was quantified by the rotarod test. The horizontal movement (C) and vertical movement (D) were measured using the open-field test. (E) The ratio of time in central zone over total time with any events of mice in the open-field test was measured. (F) The pathways traced by 12- and 18-month-old mice in the open-field test. n ≥ 10 male mice per genotype per time point. Values are mean±SEM. *P < 0.05, **P < 0.01, ***P < 0.001 (Triple transgenic versus age-matched nTg); $P < 0.05 (Pitx3-A53T α-Syn × Tau+/− versus age-matched Pitx3-A53T α-Syn × hTau, Pitx3-A53T α-Syn × Tau+/+ and Pitx3-A53T α-Syn × Tau−/−); #P < 0.05, ###P < 0.001 (Pitx3-A53T α-Syn × hTau, Pitx3-A53T α-Syn × Tau+/+ and Pitx3-A53T α-Syn × Tau+/− versus age-matched Pitx3-A53T α-Syn × Tau−/−).