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. Author manuscript; available in PMC: 2023 Oct 26.
Published in final edited form as: J Med Chem. 2021 Aug 4;65(4):2880–2904. doi: 10.1021/acs.jmedchem.1c00598

Table 2.

3CLpro inhibition data, exploring P2sp SAR

graphic file with name nihms-1922444-t0014.jpg

IC50 values are average of at least 3 independent assays, each run as technical duplicates;

a

SARS-CoV-1 3CLpro

b

SARS-CoV-2 3CLpro