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. Author manuscript; available in PMC: 2023 Oct 26.
Published in final edited form as: J Med Chem. 2021 Aug 4;65(4):2880–2904. doi: 10.1021/acs.jmedchem.1c00598

Table 4.

Assessing antiviral efficacy of compounds, measuring in vitro viral replication.

Compound CPE Inhibition Assay EC50 (μM) Plaque Reduction Assay EC50 (μM)
Remdesivir 0.34 ± 0.01 0.43 ± 0.06
1 (ML300) 19.90 ± 6.32 28.15 ± 1.30
8 12.07 ± 0.31 14.55 ± 1.22
19 5.76 ± 1.96 7.63 ± 1.65
21 1.74 ± 0.19 1.75 ± 0.25
28 7.61 ± 1.43 11.14 ± 0.37
35 8.77 ± 1.14 16.69 ±. 2.44
36 1.98 ± 0.24 3.31 ± 0.10
37 2.93 ± 0.28 3.24 ± 0.27
38 2.30 ± 0.33 2.01 ± 0.49
39 3.81 ± 0.18 4.65 ± 0.11
40 1.91 ± 0.30 3.39 ± 0.21
41 0.497 ± 0.009 0.558 ± 0.041