TABLE 5.
Predictors of cognitive, disability, HRQL ad motor change in multivariate analysis (model using the NMSS)
| MoCA | Cognitive state | Disability | HRQL | Motor function | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter estimate (95% CI) | P | Parameter estimate (95% CI) | P | Parameter estimate (95% CI) | P | Parameter estimate (95% CI) | P | Parameter estimate (95% CI) | P | |
| Age | NS | NS | – | – | NS | NS | – | – | – | – |
| Age of onset | – | – | – | – | NS | NS | – | – | – | – |
| Gender | – | – | NS | NS | NS | NS | – | – | – | – |
| Hoehn and Yahr stage | – | – | NS | NS | – | – | NS | NS | ||
| UPDRS III total | – | – | 0.929 (0.872 to 0.990) | 0.023 | – | – | NS | NS | – | – |
| NMSS affection/cognition | – | – | 1.066 (0.997 to 1.140 | 0.062 | – | – | 0.003 (0.0003 to 0.007 | 0.077 | – | – |
| NMSS perception/hallucinations | −0.565 (−1.055 to −0.075) | 0.024 | – | – | – | – | −0.040 (−0.064 to −0.016) | 0.001 | – | – |
| NMSS sleep/fatigue | NS | NS | – | – | – | – | NS | NS | – | – |
| NMSS cardiovascular | – | – | – | – | – | – | NS | NS | – | – |
| NMSS attention/memory | NS | NS | 0.884 (0.775 to 1.007) | 0.063 | – | – | NS | NS | – | – |
| NMSS gastrointestinal | – | – | – | – | – | – | NS | NS | – | – |
| NMSS urinary | NS | NS | – | – | – | – | – | – | NS | NS |
| NMSS sexual function | – | – | – | – | – | – | NS | NS | 0.139 (−0.007 to 0.286) | 0.062 |
| NMSS ‐ miscellanea | – | – | 0.023 (0.0004 to 1.257) | 0.065 | −24.385 (−51.375 to 2.605) | 0.076 | – | – | – | – |
| EuroQoL 5D | – | – | – | – | – | – | – | – | ||
| EQ‐VAS | – | – | NS | NS | – | – | NS | NS | – | – |
| UPDRS II | – | – | NS | NS | – | – | NS | NS | – | – |
| Schwab and England | – | – | NS | NS | – | – | −.010 (−0.014 to −0.005) | <0.00001 | – | – |
UPDRS, Unified Parkinson's Disease Rating Scale; NMSS, Non‐Motor Symptom Scale; EQ, EuroQol.