Additional Table 1.

Basso, Beattie and Bresnahan locomotor rating scale

Score	Feature
0	No observable hindlimb (HL) movement
1	Slight movement of one or two joints, usually the hip and/or knee
2	Extensive movement of one joint or extensive movement of one joint and slight movement of one other joint
3	Extensive movement of two joints
4	Slight movement of all three joints of the HL
5	Slight movement of two joints and extensive movement of the third
6	Extensive movement of two joints and slight movement of the third
7	Extensive movement of all three joints of the HL
8	Sweeping with no weight support or plantar placement of the paw with no weight support
9	Plantar placement of the paw with weight support in stance only (i.e., when stationary) or occasional, frequent, or consistent weight-supported dorsal stepping and no plantar stepping
10	Occasional weight-supported plantar steps; no forelimb (FL)–HL coordination
11	Frequent to consistent weight-supported plantar steps and no FL–HL coordination
12	Frequent to consistent weight-supported plantar steps and occasional FL–HL coordination
13	Frequent to consistent weight-supported plantar steps and frequent FL–HL coordination
14	Consistent weight-supported plantar steps, consistent FL–HL coordination, and predominant paw position during locomotion is rotated (internally or externally) when it makes initial contact with the surface as well as just before it is lifted off at the end of stance; or frequent plantar stepping, consistent FL–HL coordination, and occasional dorsal stepping
15	Consistent plantar stepping and consistent FL–HL coordination and no toe clearance or occasional toe clearance during forward limb advancement; predominant paw position is parallel to the body at initial
	contact
16	Consistent plantar stepping and consistent FL–HL coordination during gait and toe clearance occurs frequently during forward limb advancement; predominant paw position is parallel at initial contact and rotated at lift off
17	Consistent plantar stepping and consistent FL–HL coordination during gait and toe clearance occurs frequently during forward limb advancement; predominant paw position is parallel at initial contact and lift off
18	Consistent plantar stepping and consistent FL–HL coordination during gait and toe clearance occurs consistently during forward limb advancement; predominant paw position is parallel at initial contact and rotated at lift off
19	Consistent plantar stepping and consistent FL–HL coordination during gait, toe clearance occurs consistently during forward limb advancement, predominant paw position is parallel at initial contact and lift off, and tail is down part or all of the time
20	Consistent plantar stepping and consistent coordinated gait, consistent toe clearance, predominant paw position is parallel at initial contact and lift off, and trunk instability; tail consistently up
21	Consistent plantar stepping and coordinated gait, consistent toe clearance, predominant paw position is parallel throughout stance, and consistent trunk stability; tail consistently up

Slight: partial joint movement through less than half the range of joint motion; Extensive: movement through more than half of the range of joint motion; Sweeping: rhythmic movement of HL in which all three joints are extended, then fully flex and extend again; animal is usually sidelying, the plantar surface of paw may or may not contact the ground; no weight support across the HL is evident; No Weight Support: no contraction of the extensor muscles of the HL during plantar placement of the paw; or no elevation of the hindquarter; Weight Support: contraction of the extensor muscles of the HL during plantar placement of the paw, or elevation of the hindquarter; Plantar Stepping: The paw is in plantar contact with weight support then the HL is advanced forward and plantar contact with weight support is reestablished; Dorsal Stepping: weight is supported through the dorsal surface of the paw at some point in the step cycle; FL-HL Coordination: for every FL step an HL step is taken and the HLs alternate; Occasional: less than or equal to half; < 50%; Frequent: more than half but not always; 51-94%; Consistent: nearly always or always; 95-100%.