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Effect of metformin on the survival of SCI mice.
All deaths were recorded within the first 2 weeks after SCI surgery. n = 10 per group. The mortality rate between groups was analyzed by the Kaplan–Meier survival analysis, and the overall differences among groups were analyzed by the Wilcoxon test followed by Tukey-Kramer post hoc test. Control: Vehicle treated; 0 dpi or 3 dpi: the first dose of metformin given immediately or 3 days post SCI, respectively. SCI: Spinal cord injury.
