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. 2021 Mar 25;16(11):2324–2329. doi: 10.4103/1673-5374.310942

Figure 5.

Figure 5

Effect of SPIO-PLL-labeled BMSCs transplantation on apoptosis in brain tissue of HIBD rats (terminal deoxynucleotidyl transferase dUTP nick-end labeling staining).

In the HIBD group, a larger amount of cell death (red arrows) was observed compared with the sham group. Following the injection of SPIO-PLL-labeled BMSCs, the rates of cell apoptosis significantly decreased, and the SPIO-PLL ic. + MG group showed more therapeutic efficiency for decreasing cell death during the late stage. Early-stage: 1 and 2 weeks after injection; late-stage: 3 and 4 weeks after injection. Scale bars: 200 µm. Data are expressed as the mean (n = 16 per group) and were analyzed by one-way analysis of variance followed by Dunnett’s post hoc test. *P < 0.05. BMSCs: Bone marrow-derived mesenchymal stem cells; HIBD: hypoxic-ischemic brain damage; ic.: intraventricular injection; MG: magnetic guidance; PLL: poly-L-lysine; SPIO: superparamagnetic iron oxide nanoparticles; tv.: tail vein injection.