Table 1.

Bioactive potential of cyanobacteria and microalgae-derived compounds against matrix metalloproteinases.^a

MMP	Compound/extract	Species	Model	Reference
Collagenase	Mycosporine-2-glycine	Aphanothece halophytica	Collagenase from Clostridium histolyticum	Tarasuntisuk et al.39
	Protein extract	Chlorella minutissima	Human breast cancer cell line MDA-MB231	Kunte and Desai40
	Chlorella-derived peptide	Chlorella sp.	Human skin fibroblasts 966SK (BCRC 60153)	Chen et al.41
	Chlorella powder	Chlorella pyrenoidosa	Human MMP-1	Cheng et al.97
	Arthrospira -derived peptide	Arthrospira maxima	Collagenase from Clostridium histolyticum	Montalvo et al.42
	Arthrospira crude protein (SPCP)	Arthrospira platensis	Human dermal fibroblast cell line (CCD-986sk)	Liu et al.98
Gelatinase	C-phycocyanin extract	Spirulina platensis	HepG2 cell line	Kunte and Desai 44
	Protein extract	Chlorella minutissima	HepG2 cell line	Kunte and Desai 40
Elastase	Tutuilamides A − C	Schizothrix sp. Coleofasciculus sp.	PPE	Keller et al.46
	Lyngbyastatin 4 Lyngbyastatin 5 Lyngbyastatin 6 Lyngbyastatin 7 Cyclodepsipeptide somamide B Tiglicamides A-C Largamides A-C	Lyngbya confervoides	PPE	Matthew et al.47 Taori et al.48 Matthew et al.50 Matthew et al.49
	Lyngbyastatin 8 Lyngbyastatin 9 Lyngbyastatin 10	Lyngbya semiplena	PPE	Kwan et al.51
	Bouillomide A Bouillomide B	Lyngbyabouillonii	PPE	Rubio et al.52
	Symplostatin 5-10	Symploca sp.	PPE Human neutrophil elastase	Salvador et al.54
	Stigonemapeptin	Stigonema sp.	PPE	Kang et al.53
	Oscillapeptins A, B, D, E Oscillapeptin G Oscillapeptilides 97-A and -B Microviridin I	Oscillatoria agardhii	PPE	Itou et al.55 Fujii et al.56
	Microviridins G and H Nostopeptins A and B	Nostoc minutum	PPE	Murakami et al.57 Okino et al.58
	Microviridins B and C Micropeptins HH978, HH960, HH992, and DR1006	Microcystis aeruginosa	PPE	Okino et al.59 Lodin-Friedman and Carmeli60 Adiv et al.61
	Molassamide	Dichothrix utahensis	PPE	Gunasekera et al.62
	Scyptolins A and B	Scytonema hofmanni	PPE	Matern et al.63
	Planktopeptins BL1125, BL843, and BL1061 Anabaenopeptins B and F	Planktothrix rubescens	HLE/PPE HLE/PPE	Grach-Pogrebinsky et al.64 Bubik et al.65
	Brunsvicamides A-C	Tychonema sp.	HLE	Sisay et al.66
	Insulapeptolides A-H	Nostoc insulare	HLE	Mehner et al.67
	Arthrospira crude protein (SPCP)	Arthrospira platensis	Human dermal fibroblast cell line (CCD-986sk)	Liu et al.98
Hyaluronidase	Polysaccharide	Nostochopsis lobatus MAC0804NAN	Hyaluronidase from bovine testes, type IV-S	Yamaguchi and Koketsu et al.75
	Ethanolic extracts	Spirulina platensis Chlorella pyrenoidosa Porphyridium purpureum Rhodosorus marinus Dunaliella salina Pleurochrysis carterae	Hyaluronidase from bovine testes, type IV-S	Fujitani et al.76
	Arthrospira-derived peptide	Arthrospira maxima	Hyaluronidase from bovine testes, type IV-S	Montalvo et al.42

^aMMP: matrix metalloproteinase; PPE: porcine pancreatic elastase; HLE: human leucocyte elastase.