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. 2021 Jul 27;11:718731. doi: 10.3389/fonc.2021.718731

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Copyright © 2021 Chen, Xie, Liu, Liu, Li, Zhang, Zhang, Wang, Zhang, Sun and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BCR/ABL1 (BA) interferes with the proportion of LSKs in murine bone marrow (BM). (A) Proportion and absolute number analysis of BM Lin^-Sca-1⁺c-Kit⁺ (LSK) cells in Scl/tTA-BA mice before and after doxycycline withdrawal. (B) Follow-up analysis of granulocyte proportion in peripheral blood (PB) of Scl/tTA-BA mice after doxycycline withdrawal. (C) Follow-up analysis of GFP⁺ cell proportion in LSKs of Scl/tTA-GFP mice. (D) Schematic design of the experiment. Results are mean ± standard error of the mean (SEM), *p < 0.05, ***p < 0.001 (A, B) was assessed by unpaired t-test.