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. 2021 Jul 27;11:718731. doi: 10.3389/fonc.2021.718731

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Copyright © 2021 Chen, Xie, Liu, Liu, Li, Zhang, Zhang, Wang, Zhang, Sun and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integrated analysis of miRNA-mRNA regulatory networks in murine CML LSKs. (A) Integrated analysis flowchart of the screened miRNAs and predicted target genes. (B, C) The correlation networks showing 431 interactions built between 14 downregulated miRNAs and 299 possible target genes (B), and 318 interactions between 8 upregulated miRNAs and 271 possible target genes (C). (D–G) Visualization of the regulatory networks enriched for four pathways including myeloid differentiation (D), cell cycle (E), anti-apoptotic pathway (F), and DNA damage (G).