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. 2021 Aug 10;95(17):e00794-21. doi: 10.1128/JVI.00794-21

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This article is made available via the PMC Open Access Subset for unrestricted noncommercial re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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FIG 1 — SARS-CoV-2 spike protein expression induces senescence markers in cells. Spike-transfected A549 cells exhibited rounding and enhanced senescence-associated β-galactosidase (SA-β-Gal) expression in the presence of SARS-CoV-2 spike protein (A). Virus-infected or spike protein-expressing A549 (B) or Huh7.5 (C) cells also exhibited induction of senescence markers p21 and p16, as well as SARS-CoV-2 spike protein expression. Expression level of actin in each lane from the same gel is shown as a total protein load for comparison. Experiments were performed in triplicate.