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Lack of relationship between the glycan hole size and maximum neutralization breadth. HIV-1 Env sequences were obtained in acute infection from RV217 (A) and RV144 (B) participants; only RV144 placebo recipients were included. Neutralization breadth was assessed against a 34-virus panel, and participants were classified as having developed >70% (red), <35% (blue), or intermediate (gray) breadth.
