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BTK is notably activated in renal macrophages in the kidneys of patients with DN. (A) Immunohistochemistry of BTK expression in the glomerulus and tubulointerstitium (scale bar, 50 µm; *P<0.05 vs. control group). (B) CD68 was co-stained with phosphorylated-BTK and BTK in the kidney (scale bar, 20 µm). BTK, Bruton's tyrosine kinase; DN, diabetic nephropathy.
