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. 2021 Jul 16;48(3):177. doi: 10.3892/ijmm.2021.5010

Figure 5.

Figure 5

BTK knockout suppresses the oxidative stress and the activation of the NLRP3 inflammasome in the kidneys of diabetic mice. (A) p-BTK/BTK expression levels in mouse kidneys were detected via WB analysis. (B) iNOS, p-p65 and p65 expression levels in mouse kidneys were detected via WB analysis. (C) NOX1 and NOX4 expression levels in mouse kidneys were detected via WB analysis. (D) NLRP3, caspase-1 and ASC expression levels in mouse kidneys were detected via WB analysis (*P<0.05 vs. WT group; #P<0.05 vs. STZ group). WT, wild-type; BTK, Bruton's tyrosine kinase; STZ, Streptozotocin; p-, phosphorylated; NLRP3, NLR family pyrin domain containing 3; iNOS, inducible nitric oxide synthase; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; WB, western blot; p-p65, phosphorylated-NF-κB p65; NOX1, nicotinamide adenine dinucleotide phosphate oxidase 1; NOX4, nicotinamide adenine dinucleotide phosphate oxidase 4.