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. 2021 Jul 27;8:711899. doi: 10.3389/fcvm.2021.711899

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Copyright © 2021 Myasoedova, Genovese, Cavallotti, Bonomi, Chiesa, Campodonico, Rondinelli, Cosentino, Baldassarre, Veglia, Pepi, Alamanni, Colombo, Marenzi and Poggio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Variables associated with long-term all-cause mortality in high-risk CAD patients. The plot shows the strength of the associations between cardiovascular risk factors or AVSc and 5-year all-cause mortality (hazard ratio–HR) and their distribution. For each variable, the results obtained from multivariable Cox LASSO regressions after 1,000 bootstrap iterations are depicted and the HR (median, 2.5th percentile, and 97.5th percentile) and significance level are reported. The y- axis represents the frequency of a specific HR, while the x-axis represents the HR estimated values. AMI, acute myocardial infarction; AVSc, aortic valve sclerosis; BMI, body mass index; CAD, coronary artery disease; eGFR, estimated glomerular filtration rate; LVEF, left ventricular ejection fraction.