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. 2021 Jul 29;15(7):e0009639. doi: 10.1371/journal.pntd.0009639

Fig 9. Influence of the IL-33/ST2 pathway on T. canis infection.

Fig 9

The IL-33/ST2 pathway during T. canis infection influences the increase of hepatic parasite load and eosinophilia in the acute phase of the infection, causing greater liver damage and granulomas. In the lungs, it contributes to an increase in the Th2 response, reduces the Th17 response, increases eosinophils, tissue inflammation and the number of granulomas. And in the chronic phase in the brain, it contributes to an increase in the parasite burden and tissue eosinophilic activity.