Table 1.
The qRT‐PCR test of circulating exosomes isolated from plasma in GDM and NGT groups
NGT (N = 61) | GDM (N=57) | t/t'/z/F | P | ||||
---|---|---|---|---|---|---|---|
|
|
|
|
||||
OGTT 0 h (mmol/L) | 4.45 ± 0.39 | 4.43 ± 0.62 | 5.20 ± 0.85 | 5.20 ± 0.91 | 5.236 | <0.001 | |
OGTT 1 h (mmol/L) | 6.75 ± 31.60 | 6.67 ± 2.47 | 11.14 ± 1.40 | 10.96 ± 1.58 | 13.857 | <0.001 | |
OGTT 2 h (mmol/L) | 5.77 ± 1.10 | 5.80 ± 1.79 | 9.19 ± 1.74 | 8.98 ± 2.04 | 7.246 | <0.001 | |
HbA1C (%) | 5.09 ± 0.35 | 5.00 ± 0.50 | 5.66 ± 0.51 | 5.50 ± 0.50 | 5.616 | <0.001 | |
Age (year) | 30.00 ± 5.63 | 29.50 ± 7.00 | 32.30 ± 4.21 | 32.00 ± 6.00 | 2.213 | 0.030 | |
Gestational weeks at delivery (days) | 276.11 ± 8.14 | 278.00 ± 14.00 | 273.46 ± 9.69 | 274.00 ± 15.00 | 1.118 | 0.264 | |
Gravidity | 2.31 ± 1.25 | 2.00 ± 2.00 | 2.44 ± 1.04 | 2.00 ± 1.00 | 0.676 | 0.499 | |
Parity | 1.46 ± 0.61 | 1.00 ± 1.00 | 1.77 ± 0.58 | 2.00 ± 1.00 | 2.502 | 0.012 | |
weight§ (kg) | 58.71 ± 11.21 | 55.00 ± 15.00 | 65.54 ± 11.15 | 65.00 ± 14.50 | 3.098 | 0.002 | |
Weight¶ (kg) | 75.12 ± 13.47 | 71.00 ± 17.50 | 80.39 ± 11.85 | 78.70 ± 13.70 | 2.424 | 0.123 | |
Increase of weight during pregnancy (kg) | 16.41 ± 4.73 | 16.00 ± 7.00 | 14.86 ± 5.06 | 15.00 ± 4.50 | 2.424 | 0.123 | |
BMI§ | 22.32 ± 3.80 | 21.49 ± 5.90 | 25.10 ± 4.10 | 24.42 ± 4.90 | 3.385 | 0.001 | |
BMI¶ | 28.59 ± 4.67 | 27.34 ± 5.60 | 30.81 ± 4.43 | 30.26 ± 4.75 | 2.168 | 0.145 | |
Increase of BMI during pregnancy | 6.26 ± 1.82 | 5.88 ± 2.78 | 5.71 ± 1.95 | 5.58 ± 1.84 | 2.168 | 0.145 | |
Systolic blood pressure¶ (mmHg) | 125.14 ± 9.03 | 126.00 ± 11.00 | 129.83 ± 17.30 | 127.50 ± 18.00 | 1.235 | 0.217 | |
Diastolic blood pressure¶ (mmHg) | 77.34 ± 5.60 | 78.00 ± 7.00 | 83.37 ± 10.89 | 83.00 ± 11.50 | 3.378 | 0.001 | |
White blood cell count¶ (×109/l) | 9.45 ± 2.31 | 8.66 ± 3.90 | 8.74 ± 1.81 | 8.80 ± 2.49 | 0.931 | 0.352 | |
Percentage of Neutrophil¶ (%) | 72.26 ± 6.83 | 71.80 ± 7.80 | 73.94 ± 6.57 | 74.43 ± 7.70 | 1.153 | 0.252 | |
Percentage of lymphocyte¶ (%) | 20.56 ± 5.24 | 20.40 ± 7.10 | 19.14 ± 5.89 | 19.00 ± 8.60 | 1.151 | 0.253 | |
Neutrophil‐lymphocyte ratio | 4.34 ± 4.47 | 3.46 ± 1.55 | 4.48 ± 2.26 | 3.98 ± 2.10 | 1.294 | 0.196 | |
Hemoglobin¶ (g/l) | 115.40 ± 11.95 | 117.00 ± 20.00 | 114.08 ± 14.86 | 111.00 ± 20.00 | 0.439 | 0.661 | |
Platelets count¶ (×109/l) | 241.86 ± 55.44 | 250.00 ± 77.00 | 212.40 ± 57.47 | 208.00 ± 87.50 | 2.377 | 0.020 | |
Abdominal circumference¶ (cm) | 103.86 ± 8.52 | 102.00 ± 8.00 | 107.75 ± 7.72 | 106.00 ± 9.50 | 0.390 | 0.534 | |
Weight of the new born baby (g) | 3418.57 ± 432.29 | 3390.00 ± 660.00 | 3666.15 ± 610.39 | 3600.00 ± 785.00 | 2.073 | 0.041 | |
MiRNA‐125b | 2.36 ± 1.48 | 2.06 ± 2.31 | 0.63 ± 1.34 | 0.60 ± 1.91 | 38.962 | <0.001 | |
MiRNA‐144 | 0.71 ± 2.45 | 0.92 ± 3.20 | 2.84 ± 2.89 | 3.14 ± 4.39 | 15.909 | <0.001 |
BMI, body mass index; GDM, gestational diabetes mellitus; HbA1c, glycated hemoglobin; MiRNA, microribonucleic acid; NGT, normal glucose tolerance; OGTT, oral glucose tolerance test.
Within one standard deviation of the mean.
Within one quarter of the median.
Before pregnancy.
Before delivery.