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. 2021 Jul 27;11:637247. doi: 10.3389/fonc.2021.637247

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Copyright © 2021 Kim, Kim, Park, Nam, Sung, Bae, Choi, Yoon, Hur and Jang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosomal miR-125b blocks TGF-β1-induced EMT and TGF-β1/SMAD pathway signaling in recipient HCC cells. Low metastatic Huh7 cells were induced to show EMT by TGF-β1. (A) Relative miR-125b expression in Huh7 cells following treatment with TGF-β1. (B) Changes of morphology observed by optical microscopy after EMT induction by TGF-β1. (C) qRT-PCR results of mRNA expression levels of EMT marker genes in cells. (D) Protein expression levels of TGF-β1-EMT pathway genes based on Western blot assay. (E) Statistical analysis of protein expression levels in cells. Relative expression levels were normalized β-actin. Data are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001.