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Summary cartoon. Schematic diagram summarizing the results. Under conditions of stress, when the levels of AMFR are high, loss of OMM proteins destabilizes the mitochondria. RETREG1 interacts with OPA1 (at the IMM) and utilizes its LIR motif to assemble a phagophore around the mitochondria. Excess AMFR also gets degraded along with the “mitoplasts” at the lysosomes by this specialized “reticulo-mito-phagy” process
