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. 2020 Jul 5;17(7):1667–1683. doi: 10.1080/15548627.2020.1781368

Figure 1.

Figure 1.

Expression and clinical significance of MIR106A-5p in NPC. (A) MIR106A-5p levels in fresh NPC and non-cancerous nasopharyngeal samples detected by qRT-PCR. P-values were calculated using two-tailed Student’s t-tests. (B) MIR106A-5p levels in NP-69 and NPC cell lines were examined by qRT-PCR (one-way ANOVA). CNE-1, CNE-2, 5–8 F, and 6–10B are human NPC cell lines; NP-69 is an immortalized normal nasopharyngeal epithelial cell line. (C) Representative MIR106A-5p ISH staining of NPC tissue microarrays, scale bar: 100 μm. (D) Statistical comparison of MIR106A-5p expression across clinical stages using one-way ANOVA. (E) The ISH staining score of MIR106A-5p in NPC tissue microarrays was defined as low expression (scores of 0–8) or high expression (scores of 9–16) by the X-tile Software. Then Kaplan-Meier analysis was used to compare overall survival using the log-rank test. All experiments were conducted with three independent replicates. All graphs show mean ± SEM of at least three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001