Figure 2.

Statins inhibit the expressions of rotavirus VP6 protein. (a) Schematic depiction of the inhibitors of cholesterol biosynthesis. Following the infection of rotavirus SA11 strain (MOI 0.7) with 50 µM atorvastatin, lovastatin, or simvastatin treatment for 48 hours respectively, the expression of rotavirus VP6 protein was observed by IF staining in Caco2 cells (b), MA104 cells (c) and HSI organoids (d). VP6 protein was green, and the nuclei of the cells were visualized by DAPI (blue). The results showed that statins significantly reduced the expression of rotavirus VP6 protein