Figure 9.

Rotavirus VP4 and VP6 proteins expressions of the combinations of atorvastatin or HMGCR knockdown and cholesterol treatment. Western blot analysis of the expressions of rotavirus VP4 protein with the combinations of 50 µM atorvastatin and 150 µM cholesterol in Caco2 cells (n = 3) (a), MA104 cells (n = 3) (b), and with the combinations of HMGCR knockdown and 150 µM cholesterol (n = 3) (c). The visual aspects of the combinations of 50 µM atorvastatin and 150 µM cholesterol in Caco2 cells (d), and MA104 cells (e), and with the combinations of HMGCR knockdown and 150 µM cholesterol treatment (f). The results showed that the combinations of atorvastatin or HMGCR knockdown and cholesterol treatment significantly increased the rotavirus replications