Figure 10.

Canonical cholesterol biosynthesis is the rate-limiting step for a rotavirus clinical isolate 026 K replication in Caco2 cells. With the rotavirus 026 K strain infection, subsequently the intracellular rotavirus RNA levels were measured by qRT-PCR, after 48 hours treated with 50 µM atorvastatin (n = 4), or lovastatin (n = 4), or simvastatin (n = 6) treatment respectively (a), in sh10952 and sh10955 HMGCR knockdown Caco2 cells (b), with 6-fluoromevalonate treatment (n = 4) (c), with ZA-A treatment (n = 5) (d), with U18666A treatment (n = 6) (e), with R-MA treatment (n = 8) (f), with cholesterol treatment (n = 8) (g). All data presented as mean ± SEM, *p < .05, **p < .01, ***p < .001