Table 1:
Characteristics of 544 units (infused or back-up) chosen for 144 patients by recipient ancestry.
| Patient Ancestry N patients (%) Weight Median (range) | N Units | TNC Content Median (range) | CD34+ Content Median (range) | TNC/ kg Dose Median (range) | CD34+/ kg Dose Median (range) | 8-allele HLA-match Median (range) |
|---|---|---|---|---|---|---|
| Europeans(n = 69, 48%) 82 kg (48–126) | 259 | 216 (122–417) | 160 (46–484) | 2.7 (1.5–7.1) | 1.9 (0.7–6.3) | 5 (2–7)* |
| Northwestern(n = 11, 8%) 91 kg (51–126) | 40 | 236 (144–417) | 198 (97–373) | 3 (1.6–5.8) | 2.2 (1.1–4.7) | 5 (3–6) |
| Eastern(n = 17, 12%) 82 kg (49–115) | 65 | 215 (136–397) | 150 (55–369) | 2.7 (1.6–7.1) | 1.9 (0.8–5.6) | 5 (3–7) |
| Southern(n = 26, 18%) 83 kg (48–115) | 100 | 205 (122–376) | 147 (46–484) | 2.5 (1.5–5.4) | 1.8 (0.7–6.3) | 5 (3–6) |
| Mixed(n = 15, 10%) 81 kg (55–116) | 54 | 216 (122–401) | 166 (86–335) | 2.6 (1.5–5) | 2 (0.8–4.7) | 5 (2–6)* |
| Non-Europeans(n = 75, 52%) 79 kg (48–138) | 285 | 197 (108–457) | 132 (29–557) | 2.5 (1.5–8.1) | 1.7 (0.6–8.3) | 5 (2–8)* |
| White Hispanic(n = 14, 10%) 84 kg (56–120) | 55 | 189 (108–441) | 157 (81–398) | 2.5 (1.5–6.4) | 1.8 (0.8–6.2) | 4 (3–6) |
| Asian(n = 21, 14%) 68 kg (48–115) | 79 | 191 (108–457) | 127 (29–320) | 2.7 (1.5–8.1) | 1.8 (0.6–5.4) | 5 (2–7)* |
| African(n = 23, 16%) 81 kg (52–138) | 84 | 189 (88–448) | 122 (47–557) | 2.4 (1.5–5.5) | 1.5 (0.6–6.8) | 5 (3–7) |
| Middle Eastern(n = 4, 3%) 80 kg (59–90) | 15 | 223 (128–369) | 124 (81–177) | 2.7 (1.7–6.2) | 1.7 (1.1–2.5) | 4 (3–5) |
| Mixed non-European(n = 13, 9%) 79 kg (61–109) | 52 | 211 (93–353) | 143 (62–554) | 2.7 (1.3–4.7) | 1.7 (0.7–8.3) | 5 (3–8) |
*
One Asian patient received a unit that was re-classified as 2/8 HLA-matched upon further expert review after selection. Two additional back-up units were 2/8 HLA-matched (not infused).