Table 2:
Patient Ancestry N patients (%) Weight Median (range) | N Units | TNC Content Median (range) | CD34+ Content Median (range) | TNC/ kg Dose Median (range) | CD34+/ kg Dose Median (range) | 8-allele HLA-match Median (range) |
---|---|---|---|---|---|---|
Europeans(n = 69, 48%) 82 kg (48–126) | 137 | 232 (122–417) | 181 (54–484) | 2.8 (1.5–7.1) | 2.2 (0.7–6.3) | 5/8 (3–7) |
Northwestern(n = 11, 8%) 91 kg (51–126) | 22 | 267 (177–417) | 222 (104–373) | 3.3 (1.9–5.8) | 2.8 (1.1–4.7) | 5/8 (3–6) |
Eastern(n = 17, 12%) 82 kg (49–115) | 34 | 230 (136–397) | 179 (55–369) | 2.9 (1.8–7.1) | 2.2 (1.0–5.6) | 5/8 (3–7) |
Southern(n = 26, 18%) 83 kg (48–115) | 52 | 213 (122–349) | 174 (54–484) | 2.7 (1.5–4.8) | 1.9 (0.7–6.3) | 5/8 (3–6) |
Mixed(n = 15, 10%) 81 kg (55–116) | 29 | 238 (134–401) | 184 (90–334) | 2.7 (1.6–5.0) | 2.2 (1–4.3.0) | 5/8 (3–6) |
Non-Europeans(n = 75, 52%) 79 kg (48–138) | 149 | 216 (108–457) | 152 (47–557) | 2.8 (1.5–8.1) | 2.0 (0.6–8.3) | 5/8 (2–8)* |
White Hispanic(n = 14, 10%) 84 kg (56–120) | 28 | 212 (140–441) | 196 (96–398) | 2.8 (1.6–6.4) | 2.3 (0.8–6.2) | 5/8 (3–6) |
Asian(n = 21, 14%) 68 kg (48–115) | 42 | 194 (108–457) | 147 (51–320) | 2.8 (1.8–8.1) | 2.0 (0.7–5.4) | 5/8 (2–7)* |
African(n = 23, 16%) 81 kg (52–138) | 45 | 225 (115–448) | 144 (47–557) | 2.6 (1.5–5.5) | 1.8 (0.6–6.8) | 4/8 (3–7) |
Middle Eastern(n = 4, 3%) 80 kg (59–90) | 8 | 218 (149–369) | 141 (88–177) | 2.6 (2.0–6.2) | 1.8 (1.2–2.5) | 4.5/8 (3–5) |
Mixed non-European(n = 13, 9%) 79 kg (61–109) | 26 | 225 (134–353) | 164 (62–554) | 2.8 (1.8–4.0) | 2.0 (0.7–8.3) | 5/8 (3–8) |
One Asian patient received a unit that was re-classified as 2/8 HLA-matched post-selection upon further expert review.