Table 2.
Ligand receptors of the tastants described in the included studies. Ligand receptors for TAS2Rs
adapted from BitterDB [49]
| Tastant | Ligand receptors |
|---|---|
| Aspartame | TAS1R2/TAS1R3 heterodimer |
| Saccharin | TAS1R2/TAS1R3 heterodimer, TAS2R43, TAS2R44 |
| Sucralose | TAS1R2/TAS1R3 heterodimer, TAS2R1, TAS2R4, TAS2R5, TAS2R7, TAS2R8, TAS2R10, TAS2R39, TAS2R41, TAS2R41, TAS2R46 |
| Ace-K | TAS1R2/TAS1R3 heterodimer, TAS2R43, TAS2R44 |
| Reb-A | TAS1R2/TAS1R3 heterodimer, TAS2R4, TAS2R14 |
| Xylitol | TAS1R2/TAS1R3 heterodimer |
| Erythritol | TAS1R2/TAS1R3 heterodimer |
| Naringin | N/A |
| Quinine | TAS2R4, TAS2R7, TAS2R10, TAS2R14, TAS2R39, TAS2R40, TAS2R43, TAS2R44, TAS2R46 |
| QHCl | TAS2R4, TAS2R7, TAS2R10, TAS2R14, TAS2R39, TAS2R40, TAS2R43, TAS2R44, TAS2R46 |
| DB | TAS2R4, TAS2R8, TAS2R10, TAS2R13, TAS2R39, TAS2R43, TAS2R46, TAS2R47 |
| Bitter secoiridoids (Gentiana lutea extract, contains amarogentin) | TAS2R1, TAS2R4, TAS2R39, TAS2R43, TAS2R46, TAS2R47, TAS2R50 |
| Raisin flavor | N/A |
| Sucrose octaacetate | TAS2R46 |
| Quassia extract | TAS2R4, TAS2R10, TAS2R14, TAS2R46, TAS2R47 |
| Amarasate extract | N/A |
| MSG | TAS1R1/TAS1R3 heterodimer |
TAS1R taste receptor 1, TAS2R taste receptor, 2Ace-K acesulfame potassium, Reb-A rebaudioside A, N/A no data available, QHCL quinine hydrochloride, DB denatonium benzoate, MSG monosodium glutamate