Table 1.

Notation for optimization models

Sets
I	Set of demand locations (of suspected stroke).
J	Set of potential stroke centre locations.
C	Set of treatments types (C = {IV T, IAT}).
Parameters
P(IAT)	Probability that patient requires IAT treatment.
wi	Demand at location i.
dij	Travel time from location i to location j.
rc	Minimum number of patients with treatment c.
pc	Maximum number of stroke centres that provide treatment type c.
bj, IAT	In-hospital delay before start of IAT for stroke centre j.
Decision variables
yij	1 if demand point i is assigned to PSC j for IVT, 0 otherwise.
vij	Flow of patients from PSC i to CSC j for IAT at location j.
hjc	1 if treatment of type c is given at location j, 0 otherwise.