Our results suggest a favorable efficacy and safety profile of the new CGRP pathway drug class compared with topiramate for episodic migraine prophylaxis.

Based on the likelihood to help or harm, patients treated with a CGRP receptor (R) monoclonal antibody (mAb) are 19.2 times more likely to be helped compared with patients treated with topiramate.

Patients treated with topiramate have a higher risk of experiencing adverse reactions and discontinuing treatment compared with patients treated with a CGRP(R) mAb (placebo-subtracted risk: 12% and 1%, respectively; p = 0.005).