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. 2021 Jul 8;226(7):2243–2264. doi: 10.1007/s00429-021-02321-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Schematic representation of the experiment. (A) Timeline of a paradigm of a rat model of ethanol self-administration showing stable ethanol drinking after 21 weeks of acquisition following abstinence and fluoxetine treatment (10 mg/kg/day) for 14 days, and ethanol drinking reinstatement for 3 weeks. (B) Weekly average of ethanol intake (g/kg) were represented during ethanol self-administration baseline (week 21) and reinstatement (weeks 24–26). Tukey’s test: *p < 0.05 vs. vehicle. (C) Schematic representation of the brain regions analyzed