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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Cancer Immunol Res. 2021 Mar 11;9(6):682–692. doi: 10.1158/2326-6066.CIR-20-0492

Figure 1. Immunoproteasome expression in the TME is crucial for optimal CTL-mediated anti-tumor responses.

Figure 1.

(A) Kaplan-Meier plots of melanoma patient survival depending on expression (FPKM, lower and upper quartile) of the respective immunoproteasome subunits (TCGA datasets). Number of patients per group indicated in the panel. (B-G) B16-F10 melanoma cells were transplanted subcutaneously into WT and immunoproteasome-deficient TKO mice (n=9 mice/group) for 15 days. (B-D) Tumor volume and tumor mass were analyzed. (E) Representative contour plots of CD4+ and CD8+ T cells in mice. Bar graphs of (F) frequencies and (G) cell numbers of CD8+ and IFNγ+CD8+ T cells in tumors. One out of three independent experiments with n=3 mice/condition. (B-G). Data were analyzed by two-tailed unpaired Student’s t-test (*P=0.01–0.05, **P=0.001–0.01, mean±s.e.m).