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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Cancer Immunol Res. 2021 Mar 11;9(6):682–692. doi: 10.1158/2326-6066.CIR-20-0492

Figure 6. Schematic overview showing opposing activities of immunoproteasomes in two different cancer types.

Figure 6.

Immunoproteasomes promote development of colon cancer associated with chronic inflammation by recruiting immune cells and by regulating the expression of pro-tumorigenic cytokines and chemokines in inflamed tissues. In contrast, in melanoma, immunoproteasomes are crucial anti-tumorigenic molecules supporting the function of APCs and T lymphocytes, leading to optimal CTL-mediated anti-tumor immunity.