Skip to main content
. Author manuscript; available in PMC: 2022 Aug 20.
Published in final edited form as: Free Radic Biol Med. 2021 Jun 3;172:82–89. doi: 10.1016/j.freeradbiomed.2021.05.039

Figure 6. Model of systemic redox exerkine signaling is gated by muscle stimulation intensity.

Figure 6.

High intensity muscle contraction induces release of a redox active exerkine that travels through the blood stream and acts on unstimulated skeletal muscle. This effect is not seen in low intensity contralateral control muscle, suggesting the redox exerkine release from skeletal muscle is intensity gated. In other words, this redox exerkine is only released upon stimuli above a certain stress threshold or is released at lower intensities but not at sufficient concentrations to cause signaling effects in other tissues.