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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: J Allergy Clin Immunol. 2021 May 4;148(2):293–308. doi: 10.1016/j.jaci.2021.03.049

FIG 4.

FIG 4.

MRGPRX2 single nucleotide polymorphisms (SNPs). (A) Snake diagram of secondary structure of MRGPRX2 with each circle representing amino acid residue with one letter code. Solid background in red denotes deleterious and green denotes tolerated SNPs in MRGPRX2. (B) SNPs for ligand binding (purple), G protein coupling (green) and β-arrestin binding (blue) are shown. Conserved sequence on MRGPRX2 for β-arrestin binding (β-arrestin recruitment code) and mutations identified within this code are also shown.