Table 1.
Patient Characteristics
| Variable | Disease severity by Patient Oriented Eczema Measure (POEM) | |||
|---|---|---|---|---|
|
| ||||
| Mild (n=30) | Moderate (n=75) | Severe (n=75) | P-value | |
| Male, n (%) | 18 (60.0) | 40 (53.3) | 42 (56.0) | 0.82 |
| Age, mean (SD) | 11.1 (3.7) | 10.6 (3.6) | 11.0 (3.6) | 0.78 |
| Race, n (%) | 1.00 | |||
| Black | 10 (33.3) | 24 (32.0) | 24 (32.0) | |
| White | 11 (36.7) | 27 (36.0) | 27 (36.0) | |
| Other | 9 (30.0) | 24 (32.0) | 24 (32.0) | |
| Hispanic/Latino, n (%) | 2 (6.7) | 11 (14.7) | 10 (13.3) | 0.58 |
|
| ||||
| Parent POEM, mean (SD) | 5.1 (1.9) | 11.6 (2.3) | 21.0 (3.2) | <0.01 |
| Child POEM, mean (SD) (n=133) | 4.2 (2.6) | 11.5 (5.1) | 18.5 (7.0) | <0.01 |
|
| ||||
| Region, n (%) | 0.77 | |||
| Northeast | 4 (13.3) | 11 (14.7) | 13 (17.3) | |
| South | 12 (40.0) | 32 (42.7) | 26 (34.7) | |
| Midwest | 6 (20.0) | 14 (18.7) | 10 (13.3) | |
| West | 8 (26.7) | 18 (24.0) | 26 (34.7) | |
| Rural/Urban, n (%) | 0.34 | |||
| Urban | 13 (43.3) | 32 (42.7) | 27 (36.0) | |
| Suburban | 13 (43.3) | 34 (45.3) | 44 (58.7) | |
| Rural | 4 (13.3) | 9 (12.0) | 4 (5.3) | |
|
| ||||
| Asthma, n (%) | 7 (23.3) | 13 (17.3) | 11 (14.7) | 0.57 |
| Allergic Rhinitis, n (%) | 12 (40.0) | 25 (33.3) | 15 (20.0) | 0.07 |
| Food Allergy, n (%) | 7 (23.3) | 21 (28.0) | 28 (37.3) | 0.28 |
| ADHD, n (%) | 2 (6.7) | 16 (21.3) | 12 (16.0) | 0.19 |
|
| ||||
| Parental Education, n (%) | <0.01 | |||
| Associate’s Degree or below | 22 (73.3) | 38 (50.7) | 21 (28.0) | |
| Bachelor’s Degree | 6 (20.0) | 21 (28.0) | 23 (30.7) | |
| Master’s Degree or higher | 2 (6.7) | 15 (20.0) | 31 (41.3) | |
| Household Income, n (%) | 0.97 | |||
| Under $50,000 | 13 (43.3) | 37 (49.3) | 34 (45.3) | |
| $50,000 to <$100,000 | 12 (40.0) | 25 (33.3) | 29 (38.7) | |
| >$100,000 | 3 (10.0) | 10 (13.3) | 8 (10.7) | |
| Parental Age, mean (SD) | 41.4 (5.8) | 39.6 (6.5) | 41.2 (6.1) | 0.20 |
|
| ||||
| BMI, mean (SD) | 21.0 (5.8) | 18.5 (4.4) | 18.8 (4.0) | 0.03 |
|
| ||||
| Parent-Proxy Reported Sleep Timing/Habits | ||||
| Bed time, weekdays, mean hh:mm (SD) | 21:14 (1:00) | 21:30 (0:59) | 21:29 (1:09) | 0.45 |
| Bed time, weekends, mean hh:mm (SD) | 22:23 (1:30) | 22:32 (1:39) | 22:19 (1:40) | 0.69 |
| Wake time, weekdays, mean hh:mm (SD) | 07:05 (1:26) | 07:24 (1:16) | 07:15 (1:40) | 0.60 |
| Wake time, weekends, mean hh:mm (SD) | 8:51 (1:48) | 8:44 (1:40) | 8:50 (1:46) | 0.93 |
| Sleep Onset Latency, weekdays, n (%) | 0.32 | |||
| ≤30 minutes | 20 (66.7) | 43 (57.3) | 38 (50.7) | |
| >30 minutes | 10 (33.3) | 32 (42.7) | 37 (49.3) | |
| Sleep Onset Latency, weekends, n (%) | 0.63 | |||
| ≤30 minutes | 21 (70.0) | 47 (62.7) | 45 (60.0) | |
| >30 minutes | 9 (30.0) | 28 (37.3) | 30 (40.0) | |
| Naps on weekdays, n (%) | 9 (30.0) | 20 (26.7) | 27 (36.0) | 0.46 |
| Naps on weekends, n (%) | 5 (16.7) | 16 (21.3) | 16 (21.3) | 0.85 |
|
| ||||
| Parent-Proxy Reported Sleep, mean (SD) | ||||
| Sleep Disturbance | 55.7 (7.5) | 59.8 (10.8) | 67.1 (9.5) | <0.01 |
| Sleep-Related Impairment | 52.6 (11.8) | 57.4 (7.8) | 62.1 (12.6) | 0.03 |
|
| ||||
| Child Reported Sleep, mean (SD) (n=133) | ||||
| Sleep Disturbance | 60.5 (7.8) | 65.0 (7.8) | 70.3 (7.2) | <0.01 |
| Sleep-Related Impairment | 56.9 (9.9) | 63.9 (8.8) | 67.7 (10.8) | <0.01 |
|
| ||||
| Parent-Proxy Reported PROMIS Profile, mean (SD) | ||||
| Depression/Sadness | 49.8 (9.3) | 55.4 (10.8) | 62.3 (13.1) | <0.01 |
| Peer Relationships | 40.9 (11.1) | 43.0 (9.7) | 43.2 (9.1) | 0.51 |
| Anxiety | 48.9 (10.9) | 55.5 (11.1) | 62.0 (14.1) | <0.01 |
| Physical Function/Mobility | 50.3 (8.3) | 45.4 (9.8) | 40.1 (9.9) | <0.01 |
| Pain Interference | 52.6 (9.0) | 57.4 (7.7) | 60.7 (7.9) | <0.01 |
|
| ||||
| Child Reported PROMIS Profile, mean (SD) (n=133) | ||||
| Depression/Sadness | 49.3 (9.4) | 54.4 (10.7) | 57.7 (11.4) | 0.01 |
| Peer Relationships | 44.4 (10.7) | 46.5 (10.9) | 43.4 (10.1) | 0.27 |
| Anxiety | 46.8 (10.3) | 52.1 (11.7) | 56.1 (12.5) | 0.01 |
| Physical Function/Mobility | 51.2 (9.1) | 47.7 (10.3) | 41.6 (9.9) | <0.01 |
| Pain Interference | 46.9 (9.7) | 54.0 (9.6) | 59.3 (8.4) | <0.01 |
|
| ||||
| CDLQI, mean (SD) | 6.2 (6.5) | 11.7 (7.1) | 16.8 (6.6) | <0.01 |
|
| ||||
| Parent-Reported PIQ-C, mean (SD) | 43.4 (7.6) | 50.5 (7.2) | 57.3 (7.1) | <0.01 |
| Child-Reported PIQ-C, mean (SD) (n=133) | 40.7 (8.6) | 48.5 (9.1) | 53.9 (7.9) | <0.01 |
|
| ||||
| Inattention, MacArthur Score, mean (SD) | 0.6 (0.6) | 0.9 (0.6) | 1.1 (0.5) | <0.01 |
|
| ||||
| Impulsivity, MacArthur Score, mean (SD) | 0.5 (0.6) | 0.8 (0.6) | 1.0 (0.6) | <0.01 |
|
| ||||
| Parent-Reported Itch NRS, mean (SD) | 3.8 (2.2) | 5.4 (1.9) | 7.6 (1.3) | <0.01 |
| Child-Reported Itch NRS, mean (SD) (n=133) | 3.4 (2.5) | 5.2 (2.4) | 7.1 (2.2) | <0.01 |
*
POEM=Patient Oriented Eczema Measure; ADHD=Attention Deficit Hyperactive Disorder; BMI=Body Mass Index; PROMIS= Patient-Reported Outcomes Measurement Information System; CDLQI=Children’s Dermatology Life Quality Index; PIQ-C=PROMIS Pediatric Itch Questionnaire-Child; NRS=Numeric Rating Scale; hh:mm= hours: minutes