Table 4.
Association of sleep disturbance* with psychologic symptoms and neurocognitive function.
| Crude β [95% CI] | P-value | POEM adjust Adj β [95% CI]** |
P-value | POEM+NRS itch Adj β [95% CI]** |
P-value | Fully-adjusted Adj β [95% CI]*** |
P-value | |
|---|---|---|---|---|---|---|---|---|
| Parent proxy response 5–17 years (n=180) | ||||||||
| PROMIS pediatric profile | ||||||||
| Sleep-related impairment | 1.08 [0.96, 1.19] | <.0001 | 1.00 [0.85, 1.14] | <.0001 | 1.00 [0.84, 1.15] | <.0001 | 1.01 [0.86, 1.17] | <.0001 |
| Depression | 0.89 [0.71, 1.08] | <.0001 | 0.74 [0.53, 0.95] | <.0001 | 0.72 [0.51, 0.93] | <.0001 | 0.67 [0.46, 0.88] | <.0001 |
| Fatigue | 0.96 [0.79, 1.12] | <.0001 | 0.88 [0.69, 1.07] | <.0001 | 0.87 [0.69, 1.06] | <.0001 | 0.76 [0.56, 0.97] | <.0001 |
| Peer relationships | −0.06 [−0.28, 0.15] | 0.55 | −0.08 [−0.36, 0.20] | 0.57 | −0.08 [−0.38, 0.22] | 0.61 | −0.10 [−0.43, 0.23] | 0.54 |
| Anxiety | 0.93 [0.73, 1.14] | <.0001 | 0.79 [0.55, 1.03] | <.0001 | 0.81 [0.58, 1.05] | <.0001 | 0.79 [0.57, 1.01] | <.0001 |
| MacArthur HBQ ADHD symptoms | ||||||||
| Inattention | 0.03 [0.02, 0.05] | <.0001 | 0.03 [0.02, 0.04] | <.0001 | 0.03 [0.02, 0.04] | <.0001 | 0.03 [0.02, 0.04] | <.0001 |
| Impulsivity | 0.03 [0.02, 0.04] | <.0001 | 0.02 [0.01, 0.04] | <.0001 | 0.03 [0.02, 0.04] | <.0001 | 0.02 [0.01, 0.04] | <.0001 |
|
| ||||||||
| Child self-report 8–17 years (n=133) | ||||||||
| PROMIS pediatric profile | ||||||||
| Sleep-related impairment | 0.93 [0.82, 1.05] | <.0001 | 0.81 [0.66, 0.95] | <.0001 | 0.79 [0.62, 0.96] | <.0001 | 0.87 [0.71, 1.03] | <.0001 |
| Depression | 0.67 [0.48, 0.86] | <.0001 | 0.60 [0.39, 0.81] | <.0001 | 0.66 [0.47, 0.84] | <.0001 | 0.66 [0.46, 0.86] | <.0001 |
| Fatigue | 0.83 [0.71, 0.96] | <.0001 | 0.69 [0.52, 0.86] | <.0001 | 0.67 [0.49, 0.86] | <.0001 | 0.69 [0.51, 0.87] | <.0001 |
| Peer relationships | −0.13 [−0.37, 0.10] | 0.27 | −0.11 [−0.41, 0.20] | 0.48 | −0.13 [−0.45, 0.20] | 0.44 | −0.13 [−0.48, 0.22] | 0.46 |
| Anxiety | 0.69 [0.51, 0.87] | <.0001 | 0.61 [0.40, 0.82] | <.0001 | 0.68 [0.49, 0.87] | <.0001 | 0.69 [0.49, 0.88] | <.0001 |
*
PROMIS T-score parent-proxy sleep disturbance or child self-report sleep disturbance, respectively
**
Adjusted for POEM composite severity score without sleep or itch items
***
Adjusted for POEM composite without sleep or itch items, itch NRS, and significant socio-demographics from Table 2