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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Drug Alcohol Depend. 2021 Jun 24;226:108843. doi: 10.1016/j.drugalcdep.2021.108843

Table 1:

Psychotropic-drug-induced deaths relative to all deaths within ICD-10 underlying cause of death categories

All years 1999-2019 1999 2019

All deaths Psychotropic-drug-implicated are about 1 in X deaths All deaths Psychotropic-drug-implicated are about 1 in X deaths All deaths Psychotropic-drug-implicated are about 1 in X deaths



Medical
 Diseases of the circulatory system 17,855,050 709 954,339 1,564 874,613 434
 Diseases of the respiratory system 5,187,487 1,888 229,863 3,065 271,026 1,173
 Endocrine, nutritional and metabolic diseases 2,254,532 1,200 92,872 2,902 140,107 783
 Diseases of the digestive system 1,979,096 1,533 82,876 2,590 112,894 957
 Certain infectious and parasitic diseases 1,400,955 1911 59,984 3,749 64,706 980
 Neoplasms 12,349,887 23,346 563,065 62,563 615,191 12,555
 Diseases of the nervous system 3,054,820 8,753 84,077 7,643 233,715 7,791
 Diseases of the genitourinary system 1,337,306 5,619 53,127 5,313 72,871 3,644
 Mental and behavioral disorders, unrelated to drugs 1,947,228 8,466 33,509 2,234 118,796 10,800
 Congenital malformations, deformations and chromosomal abnormalities 212,302 1,302 10,393 2,598 9,713 883
 Pregnancy, childbirth and the puerperium 17,553 112 406 1,103 158
 Diseases of the musculoskeletal system and connective tissue 291,083 2,156 13,347 1,668 14,553 1,617
 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism 209,777 2,037 9,067 2,267 10,815 1,082
 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified 711,692 15,815 26,672 8,891 32,408 6,482
 Certain conditions originating in the perinatal period 271,207 7,534 14,259 14,259 10,412 10,412
 Diseases of the skin and subcutaneous tissue 89,668 1,546 3,697 5,229 475
 Diseases of the ear and mastoid process 1,483 1,483 74 90
 Diseases of the eye and adnexa 999 44 56
External
 Transport accidents 896,725 241 45,927 901 41,143 78
 Intentional self-harm, non-poisoning 663,023 203 24,287 347 41,353 126
 Accidental drowning and submersion 74,207 30 3,529 104 3,692 13
 Event of undetermined intent non-drug 36,853 35 1,405 48 2,093 18
 Falls 531,413 511 13,162 2,632 39,443 443
 Assault non-drug 362,859 376 16,709 726 18,777 174
 Other accidental threats to breathing 129,639 161 5,503 550 7,076 124
 Intentional self-poisoning by non-drug or alcohol 30,206 42 1,688 84 1,302 26
 Exposure to forces of nature 29,141 45 1,488 124 1,806 27
 Exposure to smoke, fire, hot substances, non-natural heat & cold, electricity, radiation 71,453 113 3,950 658 3,069 43
 Accidental poisoning by non-drug or alcohol 19,847 33 711 102 1,310 18
 Accidental poisoning by and exposure to alcohol 30,525 58 320 32 2,291 57
 All other external causes 182,439 546 9,463 1,577 8,815 294
 Legal intervention and operations of war 9,849 35 399 67 653 19
 Exposure to inanimate or animate mechanical forces 56,443 271 2,953 422 2,593 123
 Complications of medical and surgical care 61,535 392 2,742 343 5,258 1,052
 Intentional self-poisoning by and exposure to alcohol 771 9 24 3 46 9