Table 1.
Patient Characteristics for Overall Group and for Each BMI Category*
| Clinical Characteristics | Overall (n = 210) | Healthy/Underweight (n = 120) | Overweight (n = 42) | Obese (n = 48) |
|---|---|---|---|---|
| Median age at diagnosis in years (IQR) | 5.0 (3.2–8.7) | 5.0 (3.3–8.4) | 5.0 (3.2–8.3) | 5.3 (2.9–10.3) |
| Median age at assessment in years (IQR) | 13.2 (10.5–17.6) | 13.5 (10.5–17.3) | 12.2 (10.0–17.8) | 12.8 (10.7–18.5) |
| Median time since diagnosis in years (IQR) | 7.5 (6.3–9.1) | 7.7 (6.6–9.3) | 7.2 (6.2–8.1) | 7.3 (6.2–8.9) |
| Sex, n (%) | ||||
| Female | 102 (48.6) | 55 (45.8) | 23 (54.8) | 24 (50.0) |
| Male | 108 (51.4) | 65 (54.2) | 19 (45.2) | 24 (50.0) |
| Race, n (%) | ||||
| White | 155 (73.8) | 92 (76.7) | 31(73.8) | 32 (66.7) |
| Black | 26 (12.40) | 14 (11.7) | 7 (16.7) | 5 (10.4) |
| Other† | 29 (13.8) | 14 (11.7) | 4 (9.5) | 11 (22.9) |
| Treatment risk, n (%) | ||||
| Low | 121 (57.6) | 68 (56.7) | 25 (59.5) | 28 (58.3) |
| Standard/high | 89 (42.4) | 52 (43.3) | 17 (40.5) | 20 (41.7) |
| Lineage, n (%) | ||||
| B cell | 181 (86.2) | 103 (85.8) | 38 (90.5) | 40 (83.3) |
| T cell | 29 (13.8) | 17 (14.2) | 4 (9.5) | 8 (16.7) |
| Median BMI Z-score at diagnosis (IQR) ‡ | 0.17 (−0.46 to 1.02) | −0.17 (−0.86 to 0.39) | 0.27 (−0.32 to 0.98) | 1.39 (0.85–1.95) |
| BMI category at diagnosis, n (%) | ||||
| Healthy/underweight | 158 (75.2) | 109 (90.8) | 32 (76.2) | 17 (35.4) |
| Overweight | 25 (11.9) | 7 (5.8) | 7(16.7) | 11 (22.9) |
| Obese | 27 (12.9) | 4 (3.3) | 3 (7.1) | 20 (41.7%) |
| Median BMI Z-score at assessment (IQR) | 0.74 (0.04–1.62) | 0.17 (−0.37 to 0.51) | 1.36 (1.21–1.53) | 2.20 (1.87–2.46) |
| Median highest education of parents in years (IQR) | 14 (12–16) | 15 (12–16) | 14 (12–16) | 14 (12–16) |
Abbreviation: BMI, body mass index; IQR, interquartile range.
*
BMI category at the time of neurocognitive assessment.
†
Other race includes Hispanic/Latino (n = 15 [7.1%]), Asian (n = 5 [2.4%]), and multiple races (NOS) (n = 9 [4.3%]).
‡
For survivors aged <2 years at diagnosis, the BMI Z-score was calculated as the weight-for-height Z-score.