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. Author manuscript; available in PMC: 2022 Aug 15.
Published in final edited form as: J Immunol. 2021 Aug 2;207(4):1112–1127. doi: 10.4049/jimmunol.2000688

FIGURE 2. Role of Sca-1+ LMSCs in the production of inflammatory cytokines by macrophages and neutrophils.

FIGURE 2.

Purified Sca-1+ LMSCs were co-cultured separately with BMDMs and BMDNs at different ratios in the presence or absence of LPS and TNFα and IL-1β in culture supernatants were quantified using ELISA. LMSCs inhibited the LPS-induced secretion of TNFα (A) and IL-1β (B) in BMDMs and TNFα (C) in BMDNs at all ratios tested. Data are mean ± SEM from three independent experiments. ***, p < 0.001; ****, p < 0.0001 for the indicated comparisons. Data were analyzed using one-way ANOVA followed by Tukey’s multiple comparisons test. Med, medium.