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. Author manuscript; available in PMC: 2022 Aug 15.
Published in final edited form as: J Immunol. 2021 Aug 2;207(4):1112–1127. doi: 10.4049/jimmunol.2000688

FIGURE 6. Effect of Sca1+ LMSCs on bacterial growth and survival in K. pneumoniae-infected mice.

FIGURE 6.

Intratracheal administration of Sca1+ LMSCs 4 h after K. pneumoniae-infection reduced K. pneumoniae CFU in mouse lung (A), BALF (B), spleen (C), and liver (D) by 48 h after infection. Data are mean ± SEM from three separate experiments (n = 5 - 6 mice/group). ****, p < 0.0001 by Mann-Whitney test. (E) Mice were treated with PBS, LMSCs, or 3T3 MEFs 4 h and 24 h after infection with K. pneumoniae. Survival was monitored every 12 h for up to 15 days. Data are the mean of two pooled experiments (n = 28 mice/group) and are shown as percent survival. Significance between groups was examined by Log-rank (Mantel-Cox) test and asterisk indicates the difference between PBS and LMSC-administered mice. ****, p < 0.0001.