Table 2.
Individual associations of miR-score, ERS and PRS with CRC incidence in prospective set participants with all scores available (Ncases/controls = 181/174).
| Population | Quintilea | Cases | Controls | Model 1b | Model 2c | ||
|---|---|---|---|---|---|---|---|
| OR (95% CI)d | P valued | OR (95% CI)d | P valued | ||||
| miR-score | Q1 (< −1.38] | 6 (3.3) | 36 (20.7) | 0.33 (0.12–0.95) | 0.0388 | 0.34 (0.12–0.97) | 0.0439 |
| Q2 (−1.38, −0.91] | 14 (7.7) | 34 (19.5) | 0.82 (0.35–1.93) | 0.6552 | 0.88 (0.37–2.10) | 0.7759 | |
| Q3 (−0.91, −0.41] | 17 (9.4) | 34 (19.5) | Ref. | Ref. | |||
| Q4 (−0.41, 0.06] | 18 (9.9) | 35 (20.1) | 1.03 (0.46–2.32) | 0.9459 | 1.09 (0.48–2.50) | 0.8352 | |
| Q5 (> 0.06) | 126 (69.6) | 35 (20.1) | 7.20 (3.60–14.39) | 2.28E-08 | 7.20 (3.56–14.59) | 4.19E-08 | |
| ERS | Q1 (<3] | 34 (18.8) | 42 (24.1) | 0.83 (0.44–1.59) | 0.580 | – | – |
| Q2 (3, 4] | 30 (16.6) | 34 (19.5) | 0.91 (0.46–1.78) | 0.779 | – | – | |
| Q3 (4, 5] | 35 (19.3) | 36 (20.7) | Ref. | – | – | ||
| Q4 (5, 7] | 46 (25.4) | 34 (19.5) | 1.39 (0.73–2.65) | 0.314 | – | – | |
| Q5 (>7) | 36 (19.9) | 28 (16.1) | 1.32 (0.67–2.61) | 0.419 | – | – | |
| PRS | Q1 (<7.66] | 16 (8.8) | 35 (20.1) | 0.46 (0.21–0.97) | 0.042 | 0.49 (0.22–1.05) | 0.0680 |
| Q2 (7.66, 7.92] | 24 (13.3) | 34 (19.5) | 0.71 (0.35–1.42) | 0.331 | 0.76 (0.37–1.56) | 0.4543 | |
| Q3 (7.92, 8.15] | 35 (19.3) | 35 (20.1) | Ref. | Ref. | |||
| Q4 (8.15, 8.46] | 47 (26.0) | 35 (20.1) | 1.34 (0.71–2.55) | 0.367 | 1.24 (0.64–2.40) | 0.5250 | |
| Q5 (>8.46) | 59 (32.6) | 35 (20.1) | 1.69 (0.90–3.16) | 0.103 | 1.75 (0.92–3.34) | 0.0880 | |
miR-score microRNA risk score, ERS environmental risk score, PRS polygenic risk score, CRC colorectal cancer, OR odds ratio, CI confidence interval, Q quintile, Ref. reference category.
aQuintiles of risk score among controls.
bModel 1: without adjustment for any confounders.
cModel 2: like model 1, adjusted for age and sex.
dOR, 95% CI and two-sided P values were generated from logistic regression model.